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The bioactivation of tramadol by CYP2D6 is an important source of variability as a result of drug conversation. The analgesic efficacy of tramadol is usually drastically lessened by CYP2D6 inhibitors, for instance some SSRIs or terbinafine [114, one hundred fifteen].Tramadol intoxication was linked to the next chance of convulsions and vomiting. Th